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Bischloroanthrabenzoxocinone ((-)BABX)

Bischloroanthrabenzoxocinone ((-)BABX)

Cat no: B2176-23

Supplier: United States Biological
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Bischloroanthrabenzoxocinone ((-)BABX) is a selective inhibitor of Type II fatty acid synthesis (FASII). BABX showed IC50 values of 11.4 and 35.3ug/ml in the S. aureus and E. coli FASII assays, respectively, with comparable antibacterial activities. Type II fatty acid synthesis (FASII) is essential to bacterial cell viability and is a promising target for the development of novel antibiotics. More recently, BABX has been shown to inhibit agonist binding Liver X receptors (LXR). The receptors regulate the expression of the ABCA1 gene, which mediates the efflux of cholesterol from cells. Source: Bischloroanthrabenzoxocinone Molecular Weight: ~542.1 Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2176-23
Size: 500ug
Form: Supplied as a light orange residue.
Purity: (same/more than) 95% by HPLC
Alternative names: (-)BABX
References: 1. Determination of selectivity and efficacy of fatty acid synthesis inhibitors. Kodali, S., et al., J. Biol. Chem. 280: 1669 (2005). 2. Anthrabenzoxocinones from Streptomyces sp. as Liver X receptor ligands and antibacterial agents. Herath, K.B., et al., J. Nat. Prod. 68: 1437 (2005).

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