Home  >  Products  >  BLIMP1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, PRDM1)
BLIMP1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, PRDM1)

BLIMP1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, PRDM1)

Cat no: B2106-70G

Supplier: United States Biological
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PRDM1, an 88kD novel transcription repressor protein is a human homolog of mouse Blimp1. It belongs to the family of PRDM protein family and contains a PR domain and 5 Kruppel Like-zinc finger motifs at the C-terminal region. It plays a pivotal role in inducing and regulating terminal differentiation of B-lymphocytes. It recruits HDAC and complex of Groucho/TLE family proteins to the DNA and actively represses vital genes required for B-cell proliferation including c-myc, CIITA promoter III, CD23b and PAX-5 promoter. PRDM1 silences IFN
Catalogue number: B2106-70G
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum.
References: 1. Keller,A.D. and Maniatis,T. Identification and characterization of a novel repressor of beta-interferon gene expression. Genes Dev. 5 (5), 868-879 (1991). 2. Gyory,I., Fejer,G., Ghosh,N., Seto,E. and Wright,K.L. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. J. Immunol. 170 (6), 3125-3133 (2003). 3. Jin Yu et.al Molecular and Cellular Biology, 20 (7); 2592-2603 (April 2000) 4. Shaffer AL et.al Immunity 17(1):51-62 (2002 Jul) 5. C. Tunyaplin et.al The Journal of Immunology, 173: 1158-1165 (2004) 6. Gyory. I et.al Nat Immunol 5(3):299-308 (2004) 7. Turner CA Jr. et.al Cell Apr 22; 77(2):297-306 (1994).
Additional info: Recognizes human BLIMP-1. Species sequence homology: chimpanzee.

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