Home  >  Products  >  BLIMP1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, PRDM1)
BLIMP1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, PRDM1)

BLIMP1 (PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding Factor 1, PRDM1)

Cat no: B2106-70J

Supplier: United States Biological
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PRDM1, an 88KDa novel transcription repressor protein is a human homolog of mouse Blimp1. It belongs to the family of PRDM protein family and contains a PR domain and 5 Kruppel Like-zinc finger motifs at the C-terminal region. It plays a pivotal role in inducing and regulating terminal differentiation of B-lymphocytes. It recruits HDAC and complex of Groucho/TLE family proteins to the DNA and actively represses vital genes required for B-cell proliferation including c-myc, CIITA promoter III, CD23b and PAX-5 promoter. PRDM1 silences IFN
Catalogue number: B2106-70J
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Chang DH, Angelin-Duclos C, Calame K.BLIMP-1: trigger for differentiation of myeloid lineage.Nat Immunol. 2000 Aug;1(2):169-76. PMID: 11248811. 2. Turner CA Jr. et.al Cell Apr 22; 77(2):297-306 (1994). 3. Jin Yu et.al Molecular and Cellular Biology, 20 (7); 2592-2603 (April 2000). 4. Shaffer AL et.al Immunity 17(1):51-62 (2002 Jul). 5. C. Tunyaplin et.al The Journal of Immunology, 173: 1158-1165 (2004). 6. Gyory. I et.al Nat Immunol 5(3):299-308 (2004).
Additional info: Recognizes human BLIMP1. Species sequence homology: mouse.

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