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Bmi-1, aa252-264 (RNF51, MGC12685, BUP, Polycomb Group RING Finger Protein 4)

Bmi-1, aa252-264 (RNF51, MGC12685, BUP, Polycomb Group RING Finger Protein 4)

Cat no: B2185-01F

Supplier: United States Biological
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The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi-1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi-1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility. Applications: Suitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:30,000 Western Blot: 1:500-1:3000 detects a band at ~37kD. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2185-01F
Reactivities: Human
Hosts: Goat
Applications: ELISA, Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Murine Leukemia Viral (bmi 1) Oncogene Homolog, Oncogene BMI 1, PCGF4, Polycomb Complex Protein BMI 1, RING Finger Protein 51
References: 1. Voncken, J.W., et al., J. Biol. Chem. 280: 5178-5187 (2005). 2. Obuse, C., et al., Genes Cells 9:105-20 (2004). 3. Kim, J.H., et al., Cancer Lett 203: 217-224 (2004).
Additional info: Recognizes human Bmi-1. Species Sequence Homology: Mouse, Rat, Feline and Canine (all show 100% identity with immunogen).

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