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Bmi-1 (Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51)

Bmi-1 (Polycomb complex protein BMI-1, Polycomb group RING finger protein 4, RING finger protein 51)

Cat no: B2185-03C

Supplier: United States Biological
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he Bmi-1 protein is a member of the polycomb group (PcG) proteins. Bmi-1 has been reported as an oncogene by regulating the cell cycle inhibitors p16 and p19. Bmi-1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. Bmi-1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. Bmi-1 may regulate the self-renewal of other types of somatic stem cells, and it is also thought to inhibit aging in neurons through the suppression of p53. Several lines of evidence implicate Bmi-1 in tumorigenesis. Differential expression of Bmi-1 in a mouse model of metastatic prostate cancer vs. wild-type suggests Bmi-1 expression levels may predict response to therapy and survival in multiple types of cancer. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Optimal dilutions to be determined by the researcher. Positive Control: U20S Cell Lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2185-03C
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Bracken, A.P., et al. (2007). Genes Dev. 21(5):525-30. 2. Godlewski J., et al. (2008). Cancer Res. 68(22):9125-30. 3. Zhang F.B., et al. (2008). Br J Biomed Sci. 65(4):172-7. 4. Mohty M., et al. (2008). Blood. 112(5):2163-6. 5. Engelsen IB, et al. (2008). Br J Cancer. 98(10):1662-9.
Additional info: Recognizes murine BMI-1 (~35kD). Species Crossreactivity: human.

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