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Bmi-1 (RNF51, MGC12685, BUP, Polycomb Group RING Finger Protein 4)

Bmi-1 (RNF51, MGC12685, BUP, Polycomb Group RING Finger Protein 4)

Cat no: B2185-01E

Supplier: United States Biological
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The Bmi1 oncogene has been shown to induce telomerase activity and immortalize human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway. Bmi1 is also important in maintaining stem cells' ability to self renew. It has also been termed an oncogene with aberrant expression in various carcinomas. It has been shown to be a negative regulator of p19Arf, Ink4a (p14Arf) and tp53 known tumor repressors. Ablation of Bmi1 is required for short term survival of cancer cells. Positive Control: Human and mouse skeletal muscle Applications: Suitable for use in Western Blot, Immunocytochemistry and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: A band is seen at ~37kD. Some less intense non-specific bands are also present. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2185-01E
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunocytochemistry, Immunofluorescence, Western Blot
Size: 100ul
Form: Supplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Murine Leukemia Viral (bmi 1) Oncogene Homolog, Oncogene BMI 1, PCGF4, Polycomb Complex Protein BMI 1, RING Finger Protein 51
References: 1. Mori, T., et al, Mol. Cell Biol., 25(12): 5183-5195 (2005). 2. Satijn, DPE., et al, Mol. Cell Biol., 17(7): 4105-4113 (1997). 3. Obuse, C., et al, Genes to Cells, 9:105-120 (2004).
Additional info: Recognizes human Bmi-1. Species Crossreactivity: mouse

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