Bmi-1 (RNF51, MGC12685, BUP, Polycomb group RING finger protein 4)

Cat no: B2185-02B

Supplier: United States Biological

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Description
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Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. Applications: Suitable for use in Western Blot and Dot Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	B2185-02B
Hosts:	Mouse
Applications:	Western Blot
Size:	50ug
Form:	Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
P type:	Mab
Isotype:	IgG1
Purity:	Purified by Protein G affinity chromatography.
Alternative names:	PCGF4
Additional info:	Recognizes human Bmi-1.

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Bmi-1 (RNF51, MGC12685, BUP, Polycomb group RING finger protein 4)

Cat no: B2185-02B

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