Home  >  Products  >  Bombesin (BN, Gastrin Releasing Peptide, Gastrin-releasing Peptide, GRP, Neuromedin C, Neuromedin-C, Pre-progastrin Releasing Peptide, PreproGRP, ProGRP)
Bombesin (BN, Gastrin Releasing Peptide, Gastrin-releasing Peptide, GRP, Neuromedin C, Neuromedin-C, Pre-progastrin Releasing Peptide, PreproGRP, ProGRP)

Bombesin (BN, Gastrin Releasing Peptide, Gastrin-releasing Peptide, GRP, Neuromedin C, Neuromedin-C, Pre-progastrin Releasing Peptide, PreproGRP, ProGRP)

Cat no: B2550-05

Supplier: United States Biological
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Bombesin (BN) is a tetradecapepide (Pyro-ENR LGN QWA VGH LM-amide) that was originally isolated from frog skin. Several BN-related peptides have been isolated from amphibians and classified into three subfamilies: Bombesin, ranatensin and phyllolitorin based upon the last three C-terminal residues. Two BN-like peptides have been identified in mammals: NMB (neuromedin B) in the ranatensin family and GRP (gastrin-releasing peptide) in the BN-family. BN-family of G-protein coupled receptors include at least four receptor subtypes: The GRP-preferring receptors (GRP-R or bb2), the NMB-preferring receptors (NMB-R or bb1) and Bombesin receptor subtype 3 (BRS-3 or bb4). These receptors share ~50% amino acid homology and bind bombesin. However, BRS-3 has much lower affinity for BN than GRP-R and NMB-R. Mammalian BN-like peptides are widely distributed in the brain and gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine activities, metabolism and behavior. Most recently, BRS-3 deficient mice have been shown to develop mild obesity, associated with hypertension, and impairment of glucose metabolism, reduced metabolic rate, increased feeding efficiency and subsequent hyperphagia. Applications: Suitable for use in Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence: 1:30-1:300 Immunohistochemistry (Paraffin): 1:400-1:2000. Treatment of tissues in Bouin
Catalogue number: B2550-05
Reactivities: Human, Chicken/Bird
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry
Size: 250ul
Form: Supplied as a liquid in PBS, 1% BSA, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Alternative names: Gastric Releasing Peptide, GRP10, GRP-10
Additional info: Recognizes Bombesin. Reacts with amphibian bombesin and its mammalian and avian homologs. Species Crossreactivity: Chicken, human.

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