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Bone Morphogenetic Protein 7 (BMP7, OP-1, Osteogenic Protein-1)

Bone Morphogenetic Protein 7 (BMP7, OP-1, Osteogenic Protein-1)

Cat no: B2553-34C

Supplier: United States Biological
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Bone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Immunohistochemistry: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2553-34C
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid 0.1M Tris-Glycine, pH7.4, 150mM sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Lavery, K., et al. (2009). Bone. 45(1):27-41. 2. Wang, L., et al. (2009). IFMBE Proceedings. 23:1369-1372. 3. Knippenberg, M., et al. (2006). Biochem Biophys Res Comm. 342(2):902-908. 4. Komaki, M., et al. (2004). J Cell Science. 117:1457-1468. 5. Shea, C., et al. (2003). Cell. Biochem. 90(6):1112-1127.
Additional info: Recognizes human BMP-7 at ~46kD. Species Crossreactivity: mouse.

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