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Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related)

Bone Morphogenic Protein 6 (BMP6, vgr-1, Vegetal Related, DVR-6, Decapentaplegic Vegetal Related)

Cat no: B2553-30J

Supplier: United States Biological
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Bone Morphogenetic Proteins (BMP) are members of the TGF beta superfamily of cytokines that affect bone and cartilage formation. Similar to other TGF beta family proteins, BMPs are highly conserved across animal species. BMPs are involved in embryogenesis and morphogenesis of various tissues and organs. BMP6 is an autocrine stimulator of chondrocyte differentiation and has been implicated in the development of embryonic kidney and urinary systems. It is involved in liver growth and differentiation, keratinocyte differentiation, and regulation of neuronal tissue development. BMP6 expression is localized to smooth muscle cells of normal cerebral blood vessels, intimal plaques and atherosclerotically changed blood vessels, further suggesting a role as a regulator of developing tissues. Applications: Suitable for use in ELISA, Neutralization and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 0.5-1.0 ug/ml. The detecton limit for recombinant human BMP-6 is ~6.2ng/well. Western Blot: 1-20ug/ml. The detection limit for recombinant human BMP6 is ~ 20ng/lane under non-reducing conditions. Neutralization: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2553-30J
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 5% trehalose.
P type: Mab
Isotype: IgG2b
Purity: Purified by Protein G affinity chromatography.
References: 1. Reddi AH Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nat Biotechnol 16:247-52 (1998). 2. Hogan BL Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 10:1580-94 (1996). 3. Celeste AJ et al. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone. Proc Natl Acad Sci U S A 87:9843-7 (1990).
Additional info: Recognizes human Bone Morphogenic Protein 6. Shows <5% crossreactivity with recombinant human BMP5 and BMP7 and no crossreactivity with recombinant human BMP2 and BMP4 under reducing conditions.

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