TGF-beta family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. Increasing evidence indicates that BMP-Smad signaling has a tumor suppressing activity and that BMPs can inhibit tumor growth. BMP-6 is abnormally expressed in breast cancer cell lines; however, its function in promoting breast cancer development is unknown. Recombinant human BMP-6 is a 26.2kD homodimeric glycoprotein consisting of two 117aa subunits, which correspond toaa 397 to 513 of the full-length BMP-6 precursor.
Source:
Recombinant protein corresponding to human BMP-6, expressed in HEK 29.
Biological Activity:
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.03-0.06ug/ml.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
VSSASDYNSS ELKTACRKHE LYVSFQDLGW QDWIIAPKGY AANYCDGECS FPLNAHMNAT NHAIVQTLVH LMNPEYVPKP CCAPTKLNAI SVLYFDDNSN VILKKYRNMV VRACGCH
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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