Bonzo, NT2 (STRL33, TYMSTR, G Protein-coupled Receptor)

Cat no: B2555-01

Supplier: United States Biological

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Description
Additional Information

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, and CCR2b in the chemokine receptor family have been identified as HIV coreceptors. An orphan G protein-coupled receptor was recently cloned and designated Bonzo, STRL33 and TYMSTR, and identified as HIV and SIV coreceptor (1-4). Bonzo/STRL33 serves as coreceptor for SIV, HIV-2 and HIV-1. The messenger RNA of Bonzo/STRL33 is expressed in lymphoid tissues and activated peripheral blood lymphocytes. Application(s):Suitable for use in Western blot. Recommended Dilution: 1:500 Positive Control: Human spleen tissue lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C or colder. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	B2555-01
Reactivities:	Human
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug
Form:	Supplied as a liquid in PBS, 0.02% sodium azide.
P type:	Pab
Isotype:	IgG
Purity:	Immunoaffinity purified IgG
References:	1. Deng HK, Unutmaz D, KewalRamani VN, Littman DR. Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 1997;388:296-300 2. Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 1997;185:2015-23 3. Alkhatib G, Liao F, Berger EA, Farber JM, Peden KW. A new SIV co-receptor, STRL33. Nature 1997;388:238 4. Loetscher M, Amara A, Oberlin E, Brass N, Legler D, Loetscher P, D
Additional info:	Recognizes human Bonzo (NT2) STRL33, TYMSTR

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Bonzo, NT2 (STRL33, TYMSTR, G Protein-coupled Receptor)

Cat no: B2555-01

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