Home  >  Products  >  Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT)
Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT)

Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT)

Cat no: B2674-75

Supplier: United States Biological
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The Brachyury protein is required for the proper formation and differentiation of posterior mesoderm and for axial development in all vertebrates. The Brachyury gene encodes a transcription factor that binds to a specific DNA element via its N-terminal region. A protein motif within the DNA-binding domain, the so-called T box, is highly conserved among T homologs from different species and also defines a broader family of T-box genes Brachyury functions during the earlier stages of gastrulation, which suggests that at least one of its early roles is to regulate the morphogenetic behavior of nascent mesoderm by altering cell autonomous properties. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2674-75
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Abe, K., Yamamura, K. And Suzuki, M. Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locus. Mammalian Genome 11: 238-240, 2000. Edwards, Y. H., Putt, W., Lekoape, K. M., Stott, D., Fox, M., Hopkinson, D. A.; and Sowden, J. The human homolog T of the mouse T (Brachyury) gene: gene structure, cDNA sequence, and assignment to chromosome 6q27. Genome Res. 6: 226-233, 1996. Huber, T. L, Kouskoff, V., Fehling, H. J., Palis, J., Keller, G. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature 432: 625-630, 2004. Jensen, L. E., Barbaux, S., Hoess, K., Fraterman, S., Whitehead, A. S. and Mitchell, L. E. The human T locus and spina bifida risk. Hum. Genet. 115: 475-482, 2004.
Additional info: Recognizes human Brachyury.

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