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Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT)

Brachyury (Brachyury Homolog, Brachyury Protein, Bry, MGC104817, T, T Protein, TFT)

Cat no: B2674-75A

Supplier: United States Biological
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The Brachyury protein is a T-box transcription factor that is one of the earliest indicators of mesoderm formation during embryonic development. As the brachyury protein family is essential for the formation of the posterior body in all vertebrates, Brachyury has been shown to be expressed during gastrula and neurula stages, as well as in the developing notochord. Consequently, when mutations occur within the brachyury gene, severe vertebral malformations have been found to occur, as a direct result. In addition, current findings also indicate that the dysregulation of brachyury may also be linked to the formation of chordomas, which are malignant tumors that develop along the spine. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2674-75A
Reactivities: Human
Hosts: Mouse
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Golob, J., et al. (2008). Developmental Dynamics. 237:1389-1398. 2. Vujovic, S., et al. (2006). J Pathol. 209:157-165. 3. Priddle., H., et al. (2006). Stem Cells. 24(4):815-824. 4. Cai, J., et al. (2005). Developmental Biology. 5:26. 5. Yamaguchi, T., et al. (1999). Genes Dev. 13:3185-3190.
Additional info: Recognizes human brachyury.

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