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Brain Derived Neurotrophic Factor (BDNF)

Brain Derived Neurotrophic Factor (BDNF)

Cat no: B2700-02L

Supplier: United States Biological
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Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT-3, and NT-4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells.1 BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non-neuronal cells.2 Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:100-1:2000 detects BDNF at ~300ng/lane under non-reducing and reducing conditions. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2700-02L
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Alternative names: Abrineurin
References: 1. Jones, K., et al., Cell, 76, 989 (1994). 2. Snider, W., Cell, 77, 627 (1994). 3. Davies, A.M., "Neurotrophic Factor Bioassay Using Dissociated Neurons" in Nerve Growth factors, Rush, R.A., (Ed), John Wiley and Sons, Ltd, pp 95-109 (1989)
Additional info: Recognizes human BDNF. Will neutralize the biological activity of rhBDNF. Shows <2% crossreactivity with rhbeta-NGF, rhNT-3 and rhNT-4 based on ELISA and Western Blot.

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