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Brain Natriuretic Peptide, Pro, NT, 61-76 (NT-proBNP, N-terminal prohormone brain natriuretic peptide)

Brain Natriuretic Peptide, Pro, NT, 61-76 (NT-proBNP, N-terminal prohormone brain natriuretic peptide)

Cat no: B2702-03P

Supplier: United States Biological
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Human brain natriuretic peptide (BNP) is a secreted protein which is a member of the natriuretic peptide family. BNP is a cardiac hormone, which is synthesized as a pro-hormone (proBNP), and is proteolytically cleaved to release a biologically active fragment (BNP), and an inactive fragment (NT-proBNP) into the circulation. BNP is predominantly secreted from the cardiac ventricles in response to volume and pressure overload, and results in a number of biological activities including natriuresis, diuresis, vasorelaxation, and inhibition of the sympathetic nervous system. A high concentration of BNP in the bloodstream is indicative of heart failure. Cellular Localization: Secreted Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2702-03P
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Western Blot
Size: 500ug
Form: PBS with 0.1% sodium azide, pH 7.4
P type: Mab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: Pfister R et al. Use of NT-proBNP in routine testing and comparison to BNP. Eur J Heart Fail 6:289-93 (2004). Hall C Essential biochemistry and physiology of (NT-pro)BNP. Eur J Heart Fail 6:257-60 (2004). Hobbs FD et al. Reliability of N-terminal pro-brain natriuretic peptide assay in diagnosis of heart failure: cohort study in representative and high risk community populations. BMJ 324:1498 (2002). Mair J et al. The impact of cardiac natriuretic peptide determination on the diagnosis and management of heart failure. Clin Chem Lab Med 39:571-88 (2001).
Additional info: Species Crossreactivity: Crossreacts with Human. Not yet tested in other species.

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