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BRCA1 (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

BRCA1 (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

Cat no: B2709-05H

Supplier: United States Biological
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Cellular Localization: Nuclear Applications: Suitable for use in Western Blot and Immunoprecipitation,. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2709-05H
Reactivities: Human
Hosts: Mouse
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Mab
Isotype: IgG1,k
Purity: Purified by immunoaffinity chromatography.
References: This product has been used in:Carneiro C et al. p27 deficiency desensitizes Rb-/- cells to signals that trigger apoptosis during pituitary tumor development. Oncogene 22:361-9 (2003). Chen Y et al. BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner. Cancer Res 56:3168-72 (1996).
Additional info: This antibody recognizes BRCA1, a 220kD nuclear phosphoprotein, and does not recognize the exon 11 splice variant. Mutations in this tumor suppressor gene greatly increase the risk of breast cancer. Species Crossreactivity: Crossreacts with Human. Not yet tested in other species.

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