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BRCA1 (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

BRCA1 (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

Cat no: B2709-05M

Supplier: United States Biological
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BRCA1 (breast and ovarian cancer susceptibility protein 1) is a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. It combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC (for BRCA1 associated genome surveillance complex). BRCA1 associates with RNA polymerase II, and through the C terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in the BRCA1 gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full length natures identified. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin): 1:10-1:2000. HEIR using 10mM citrate buffer pH6.0 Immunohistochemistry (ABC): 1:15-1:50 Optimal dilutions to be determined by the researcher. Positive Control: Ovarian carcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2709-05M
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 250ul
Form: Supplied as a liquid with sodium azide.
P type: Mab
Isotype: IgM
Purity: Tissue culture supernatant
References: 1. Kashima K et al. Screening of BRCA1 mutation using immunohistochemical staining with C-terminal and N-terminal antibodies in familial ovarian cancers. Jpn J Cancer Res 91:399-409 (2000).
Additional info: Recognizes human BRCA1. Stains 94% of ovarian carcinomas with a mutation in exon 11. However, staining is absent in 100% of tumors with mutations other than exon 11.

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