Home  >  Products  >  BRCA1, phosphorylated (Ser1423) (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)
BRCA1, phosphorylated (Ser1423) (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

BRCA1, phosphorylated (Ser1423) (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

Cat no: B2709-05D

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer. Applications: Suitable for use in Flow Cytometry and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2709-05D
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7-8, containing 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Cheng W-H, Muftic D, Muftuoglu M, et al. WRN Is Required for ATM Activation the S-Phase Checkpoint in Response to Interstr Cross-Link-Induced DNA Double-Str Breaks. Mol Biol Cell 2008;19(9):3923-3933. 2. Zaugg, K., Su, Y.-W., Reilly, P. T., Moolani, Y., Cheung, C. C., Hakem, R., Hirao, A., Elledge, S. J., Mak, T. W. (2007) Cross-talk between Chk1 Chk2 in double-mutant thymocytes, 104, 3805-3810.
Additional info: Reacts with BRCA1 phospho-Ser 1423. Species Crossreactivity: This antibody reacts with human and mouse. Other species have not been tested.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave