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BRCA1, phosphorylated (Ser1457) (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

BRCA1, phosphorylated (Ser1457) (Breast Cancer 1, Breast cancer 1 early onset, Breast cancer type 1 susceptibility protein, Breast Ovarian Cancer Susceptibility, Papillary serous carcinoma of the peritoneum, PSCP, RNF53)

Cat no: B2709-05E

Supplier: United States Biological
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BRCA 1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA 1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA 1 function confers an increased susceptibility for both breast and ovarian cancer. Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2709-05E
Reactivities: Human
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris-citrate/phosphate buffer, pH 7-8, containing 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Bekker-Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bartek, J., and Lukas, J. (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks, 173, 195-206.
Additional info: Reacts with BRCA1 phospho-Ser 1457. Species Crossreactivity: This antibody reacts with Homo sapiens. Other species have not been tested.

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