Home  >  Products  >  BRCC36 (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36, BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)
BRCC36 (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36, BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)

BRCC36 (Lys-63-specific Deubiquitinase BRCC36, BRCA1-A Complex Subunit BRCC36, BRCA1/BRCA2-containing Complex Subunit 3, BRCA1/BRCA2-containing Complex Subunit 36, BRISC Complex Subunit BRCC36, BRCC3, C6.1A, CXorf53)

Cat no: B2727-01E

Supplier: United States Biological
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BRCC-36 is a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. It is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains, and does not have activity toward 'Lys-48'-linked polyubiquitin chains. In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Applications: Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2727-01E
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 50ul
Form: Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Additional info: Recognizes human BRCC3.

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