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BRD4 (Bromodomain-containing Protein 4, Protein HUNK1, HUNK1)

BRD4 (Bromodomain-containing Protein 4, Protein HUNK1, HUNK1)

Cat no: B2852-83B

Supplier: United States Biological
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Brd4, a ubiquitously expressed nuclear phosphoprotein, is a member of BET protein family. It is a human homolog of mouse MCAP and consists of 2 N-terminal bromodomains, a central ET-domain, and several kinase-like motifs in its N-terminus. It is expressed as 2 isoforms; longer variant has a C-terminus region with a proline and glutamine-rich domains. Brf4 is a chromatin-binding protein whose expression is induced in response to growth stimuli. Brd4 acts at different stages of cell cycle by interacting with proteins including RFC and SPA-1 and regulates cell growth. It also has a role in regulating chromosomal dynamics during mitosis. Brf4 functions as a cellular target for E2 protein of papillomavirus. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 2-5ug/ml Optimal dilutions to be determined by the researcher. Positve Control: HeLa cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: B2852-83B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity Chromatography.
References: 1. Maruyama et.al Mol Cell Biol 22 (18) 6509-6520 (September 2002). 2. Farina et.al Mol Cell Biol 24 (20) 9059-9069 (October 2004). 3. McPhillips et.al J Virol 80 (19) 9530-9543 (October 2006).
Additional info: Recognizes human Brd4. BRD4 is expressed in two forms, the long form is approximately 1400 amino acids and the short form is approximately 722 amino acids. Species Crossreactivity: chimpanzee, mouse and rat

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