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Brilliant Violet 421(TM) anti-mouse LAP (TGF-beta1)

Brilliant Violet 421(TM) anti-mouse LAP (TGF-beta1)

Cat no: 141407

Supplier: BioLegend
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Transforming growth factor beta (TGF-beta) is a cytokine that has critical functions in the immune response by regulating Treg and Th17 cells. TGF-beta is first synthesized as pro-TGF-beta and then it is cleaved by furin proprotein convertase in the Golgi apparatus to produce the dimeric propeptides called latency-associate peptide (LAP) that non-covalently associates with the dimeric mature TGF-beta to prevent its activity. This complex can further associate with latent-TGF-beta-binding protein (LTBP) to produce a large latent form for deposition onto the extracellular matrix. The latent-TGF-beta can be expressed on the membrane of activated Treg cells, immature dendritic cells, megakaryocytes, and platelets.
Catalogue number: 141407
Reactivities: Mouse
Hosts: Mouse
Applications: Flow Cytometry
Size: 125 microl
Clone: TW7-16B4
Gene: 21803
Dilutions: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is ?5 microl per million cells or 5 microl per 100 microl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.Brilliant Violet 421(TM) excites at 405 nm and emits at 421 nm. The standard bandpass filter 450/50 nm is recommended for detection. Brilliant Violet 421(TM) is a trademark of Sirigen Group Ltd.
Storage buffer: The antibody solution should be stored undiluted at 4, and protected from prolonged exposure to light. Do not freeze.
Antigen: Mouse Tgfb1-transduced P3U1 cells
Isotype: Mouse IgG1, kappa
Clonality: Monoclonal
Regulatory status: RUO
Shipping temp: Ambient RT
Storage temp: 4 C
Alternative names: TGFB, TGFB1, DPD1, Latency Associated Peptide (LAP), TGF-beta1, TGF-beta
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