BTK (7F12) Antibody

Cat no: 252705

Supplier: ABBIOTEC

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Description
Additional Information

BTK (Tyrosine-protein kinase BTK) is a tyrosine kinase that plays a crucial role in B-cell ontogeny. Defects in BTK are the cause of , Xenopus/Amphibian,-linked agammaglobulinemia (, Xenopus/Amphibian,LA) also known as , Xenopus/Amphibian,-linked agammaglobulinemia type 1 (AGM, Xenopus/Amphibian,1) or immunodeficiency type 1 (IMD1). , Xenopus/Amphibian,LA is a humoral immunodeficiency disease which results in developmental defects in the maturation pathway of B-cells. Affected boys have normal levels of pre-B-cells in their bone marrow but virtually no circulating mature B-lymphocytes. This results in a lack of immunoglobulins of all classes and leads to recurrent bacterial infections.

Catalogue number:	252705
Reactivities:	Human, Mouse
Applications:	Immunofluorescence, Immunohistochemistry
Size:	0.1 ml
Accession:	Q06187
Antigen:	Purified recombinant fragment of BTK e, Xenopus/Amphibian,pressed in E. coli.
Format:	Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1
Clonality:	7F12H4
Additional info:	BTK; Tyrosine-protein kinase BTK; Bruton tyrosine kinase; Agammaglobulinaemia tyrosine kinase; ATK; B-cell progenitor kinase; BPK; AGM, Xenopus/Amphibian,1; ATK; BPK