BTLA, Fc Chimera, Recombinant, Mouse (B- and T-Lymphocyte Attenuator, CD272)

B- and T-lymphocyte attenuator (BTLA; CD272) is a 70kD, Ig-superfamily, type I transmembrane glycoprotein that is structurally similar to the CD28 family of T cell costimulatory or coinhibitory molecules. (1-3) Unlike CD28 family members, however, the BTLA extracellular Ig domain is an I-type rather than V-type domain, and BTLA does not form homodimers. (4) BTLA also differs from CD28 family members through the interaction of its Ig domain with the TNF superfamily member HVEM (Herpes virus entry mediator; TNFSF14) rather than with B7 family ligands. (5) BTLA is a coinhibitory molecule expressed on T cells, B cells and, depending on the mouse strain, macrophages, dendritic and NK cells. (6) Expression is low in na

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SPECIFICATIONS

Catalog Number

B5003-10

Size

50ug

Form

Supplied as a lyophilized powder in PBS, 5% trehalose.

Purity

(same/more than) 90%, as determined by SDS-PAGE and visualized by silver stain.

References

1. Murphy, K. M. et al., 2006, Nat. Rev. Immunol. 6:671. \n2. Croft, M., 2005, Trends Immunol. 26:292. \n3. Watanabe, N. et al., 2003, Nat. Immunol. 4:670. \n4. Compaan, D. M. et al., 2005, J. Biol. Chem. 280:39553. \n5. Sedy, J. R. et al., 2005, Nat. Immunol. 6:90. \n6. Hurchla, M. A. et al., 2005, J. Immunol. 174:3377. \n7. Krieg, C. et al., 2007, Nat. Immunol. 8:162. \n8. Gavrieli, M. et al., 2003, Biochem. Biophys. Res. Commun. 312:1236. \n9. Chemnitz, J. M. et al., 2006, J. Immunol. 176:6603.