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BubR1 (Bub1b, Bub1A, MAD3L, budding uninhibited by benzimidazoles related 1, budding uninhibited by benzimidazoles 1 homolog beta, mitotic arrest deficient-like 3 like)

BubR1 (Bub1b, Bub1A, MAD3L, budding uninhibited by benzimidazoles related 1, budding uninhibited by benzimidazoles 1 homolog beta, mitotic arrest deficient-like 3 like)

Cat no: B2790-40B

Supplier: United States Biological
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Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1. Cellular Localization: Nuclear Applications: Suitable for use in Immunofluorescence and Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: B2790-40B
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 100ul
Form: As reported
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
References: 1. Zhou, J., et al. Paclitaxel-resistant human ovarian cancer cells undergo c-Jun NH2-terminal kinase-mediated apoptosis in response to noscapine. J. Biol. Chem. 277:39777-39785, 2002. (Western blot, immunofluorescence, immunoprecipitation, human) 2. Liu, S., et al. Human CENP-I specifies localization of CENP-F MAD1 and MAD2 to kinetochores and is essential for mitosis. Nature Cell Biol. 5(4):341-345, 2003.
Additional info: Specific for hBUBR1. There should be no crossreactivity with hBUB1. Species Crossreactivity: Human and mouse. Other species have not been tested.

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