Burkholderia mallei is the causative agent of glanders, an infectious disease found mostly in horses. Glanders is characterised by nodular lesions in the lung and ulcers in the mucous membranes of the respiratory tract. Acute disease can cause death from septicaemia in a few days while chronic disease can linger for months. Humans can be infected through direct contact with an infected animal. In humans the infection may be rapidly fatal. Glanders has been eliminated in North America, Australia and most of Europe, but remains endemic in Asia, Africa, the Middle East and Central and South America.
The use of B. mallei as a biological weapon has been reported and as there is currently no vaccine available for either humans or animals it remains a possible target for biological warfare.
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
Optimal dilutions to be determined by the researcher.
Hybridoma:
Sp2/0 myeloma cells with spleen cells from Balb/c mice.
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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