Home  >  Products  >  c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)
c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)

c-Abl (ABL1, v-abl, Abelson Murine Leukemia Viral Oncogene Homolog 1, ABL, c-ABL, JTK7, p150, Proto-Oncogene Tyrosine-Protein Kanase ABL1, v-abl)

Cat no: C0013-01S

Supplier: United States Biological
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The c-Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) as the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr / Abl mRNA encoding activated Abl protein tyrosine kinase. Cellular Localization: Cytoplasmic and Nuclear Positive Control: HeLa cells or placenta. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C0013-01S
Reactivities: Human, Mouse
Hosts: Mouse
Applications: Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 500ul
Form: 10mM PBS, pH7.4, 0.2%BSA,
P type: Mab
Isotype: IgG1,l
Purity: Purified by Protein G affinity chromatography.
Alternative names: Abelson Murine Leukemia Viral Oncogene Homolog 1, Abelson murine leukemia viral v abl oncogene homolog 1, Abl 1, ABL, Abl protein, Abl1, Bcr/c abl oncogene protein, JTK 7, JTK7, p150, Proto oncogene tyrosine protein kinase ABL1, Transformation gene oncogene ABL, v abl Abelson murine leukemia viral oncogene homolog 1, v abl
References: Whang YE et al. c-Abl is required for development and optimal cell proliferation in the context of p53 deficiency. Proc Natl Acad Sci U S A 97:5486-91 (2000). <PUBMED:10805805>Sun X et al. Activation of the cytoplasmic c-Abl tyrosine kinase by reactive oxygen species. J Biol Chem 275:17237-40 (2000). <PUBMED:10770918>
Additional info: Reacts with c-Abl p120 and chimeric Bcr / Abl proteins. Species Crossreactivity: Crossreacts with Human and Mouse. Not yet tested in other species.

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