c-ABL Antibody

Cat no: 251225

Supplier: ABBIOTEC

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Description
Additional Information

Proto-oncogene c-Abl (c-ABL) is a protein kinase that regulates key processes linked to cell growth and survival. c-ABL regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. C-ABL localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. c-ABL regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. A chromosomal aberration involving c-ABL1 is a cause of chronic myeloid leukemia.

Catalogue number:	251225
Reactivities:	Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	P00519
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human c-ABL.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	ABL1; Abelson murine leukemia viral oncogene homolog 1; Proto-oncogene tyrosine-protein kinase ABL1; c-ABL; p150; ABL