Home  >  Products  >  c-Cbl (E3 Ubiquitin-protein Ligase CBL, Casitas B-lineage Lymphoma Proto-oncogene, Proto-oncogene c-Cbl, RING Finger Protein 55, Signal Transduction Protein CBL, CBL2, RNF55)
c-Cbl (E3 Ubiquitin-protein Ligase CBL, Casitas B-lineage Lymphoma Proto-oncogene, Proto-oncogene c-Cbl, RING Finger Protein 55, Signal Transduction Protein CBL, CBL2, RNF55)

c-Cbl (E3 Ubiquitin-protein Ligase CBL, Casitas B-lineage Lymphoma Proto-oncogene, Proto-oncogene c-Cbl, RING Finger Protein 55, Signal Transduction Protein CBL, CBL2, RNF55)

Cat no: C0013-26M

Supplier: United States Biological
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Casitas b-lineage lymphoma (c-Cbl) is a 120kD cytoplasmic protein product of the c-Cbl proto-oncogene and is mainly expressed in thymus. C-Cbl is a member of ubiquitin-protein ligases (E3) family. It possesses highly conservative N-terminal phosphotyrosine binding domain that allows recognition of tyrosine-phosphorylated substrates and C3HC4 RING finger motif that allows recruitment and activation of E2 ubiquitin-conjugating enzyme. Thus, c-Cbl negatively regulates many signaling pathways that employ tyrosine-kinase receptors. Recent studies demonstrated that c-Cbl is involved in thymus development and plays a major role in whole-body homeostasis. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0013-26M
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Thien C et al. (2005) Biochem J. 391: 153-166. 2. Zhang J et al. (2004) The J. of Immun. 173: 1811-1818. 3. Joazeiro C et al. (1999), Science 286(5438): 223-225. 4. Molero J et al. (2004) The J of Clin. Investig. 114: 1326-1333.
Additional info: Recognizes human c-Cbl.

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