Home  >  Products  >  c-Cbl (E3 Ubiquitin-protein Ligase CBL, Casitas B-lineage Lymphoma Proto-oncogene, Proto-oncogene c-Cbl, RING Finger Protein 55, Signal Transduction Protein CBL, CBL2, RNF55)
c-Cbl (E3 Ubiquitin-protein Ligase CBL, Casitas B-lineage Lymphoma Proto-oncogene, Proto-oncogene c-Cbl, RING Finger Protein 55, Signal Transduction Protein CBL, CBL2, RNF55)

c-Cbl (E3 Ubiquitin-protein Ligase CBL, Casitas B-lineage Lymphoma Proto-oncogene, Proto-oncogene c-Cbl, RING Finger Protein 55, Signal Transduction Protein CBL, CBL2, RNF55)

Cat no: C0013-26P

Supplier: United States Biological
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The mammalian Cbl family of ubiquitin ligases consists of three homologs known as Cbl (also known as c-Cbl), Cbl- B, and Cbl-3 which share highly conserved a tyrosine- kinase-binding domain, linker and RING finger domain in their amino-terminal halves (reviewed in 1). Similar to other E3 ubiquitin ligases, Cbl catalyzes the transfer of ubiquitin from an E2 or Ubc (ubiquitinconjugating) enzyme to the e-amino group of a lysine residue of the substrate protein. Cbl acts to negatively regulate many types of cell-surface receptors, including the Syk protein tyrosine kinase family. Cbl is thought to be involved in T- and B-cell signaling, in addition to thymus development. Of the three known homologs in the Cbl family, Cbl antibody reacts specifically with Cbl. Multiple isoforms of Cbl have been reported. Applications: Suitable for use in ELISA, Western Blot and Immunofluorescence. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Daudi cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0013-26P
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: 1. Thien CBF, et al (2005) Biochem. J. 391:153-66. 2. Weissman AM (2001) Nat. Rev. Mol. Cell Biol. 2:169-78. 3. Swaminathan G, et al (2006) J. Cell. Physiol. 209:21-43.
Additional info: Recognizes human Cbl. Species Crossreactivity: mouse and rat.

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