C/EBP (alpha) regulates gene expression in a variety of tissues including liver, adipose, lung and intestine. C/EBP (alpha) uses a bipartite structural motif to bind DNA. Two protein chains dimerize through a set of amphipathic (alpha) helices termed the leucine zipper. Highly basic polypeptide regions emerge from the zipper to form a linked set of DNA contact surfaces. C/EBP (alpha) appears to function exclusively in terminally-differentiated, growth-arrested cells. Additional family members include C/EBP (beta), C/EBP (gamma), C/EBP (delta) and C/EBP E, all of which exhibit similar DNA-binding specificities and affinities to C/EBP (alpha). Furthermore, C/EBP (beta) and C/EBP (delta) readily form heterodimers both with each other as well as with C/EBP (alpha).