Home  >  Products  >  c-erbB-2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2)
c-erbB-2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2)

c-erbB-2 (v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, CD340, C-erbB-2, HER2, HER-2, HER-2/neu, MLN 19, NEU, NEU proto-oncogene, NGL, p185erbB2, Receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2)

Cat no: C0016-01E

Supplier: United States Biological
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v-ErbB was identified as the viral counterpart of the EGF Receptor, and its relatives have adopted this nomenclature (or the HER nomenclature for human proteins). These proteins are activated by Heregulin, Neuregulin and Amphiregulin. ErbB-2/HER-2, also known as neu, is amplified in large numbers of highly aggressive breast cancers, but all the family members are capable of heterodimerization, and together activate downstream signaling pathways. ErbB-3 has a natural "substitution" at the codon which is an invariant Lys residue at the ATP-binding site of all protein kinases. It is therefore inactive as a kinase, and can only become phosphorylated by heterodimerization with another erbB-family member. All members of this family, when Tyr-phosphorylated, can nucleate the formation of signaling complexes through adapter proteins. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:1000 Immunohistochemistry: Paraffin Optimal dilutions to be determined by the researcher. Recommended Positive Control: A431 Cell Lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0016-01E
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as liquid in PBS, 1mg/ml BSA, 10mM sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes human c-erbB-2. Species Crossreactivity: mouse and rat.

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