Home  >  Products  >  c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL, Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1)
c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL, Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1)

c-erbB2 ( HER2/neu, ErbB2, ErbB-2, Tyrosine Kinase-type Cell Surface Receptor Her2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, HER2, HER-2, NEU, NGL, Neuroblastoma- or Glioblastoma-Derived Oncogene Homolog, TKR1)

Cat no: C0016-01

Supplier: United States Biological
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c-erbB-2 is a membrane-associated oncoprotein having considerable sequence homology to EGFR. C-erbB-2 is the second member of the EGF receptor tyrosine kinase family of growth factor receptors. Overexpression of c-erbB-2/HER-2 is reportedly a marker of poor prognosis in node-positive and in defined subsets of node-negative breast cancer. Elevated levels of c-erbB-2/HER-2 has also been implicated in response to chemotherapy. Applications: Suitable for use in Immunohistochemistry (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Cellular Localization: Cell Membrane Positive Control: Breast Carcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C0016-01
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid in 20mM tris-borate, 150mM sodium chloride.
P type: Pab
Isotype: IgG
Purity: Purified
References: Soomro S et al. c-erbB-2 expression in different histological types of invasive breast carcinoma. J Clin Pathol 44:211-4 (1991). May E et al. Human breast cancer: identification ohttp://www.novusbio.com/data_sheet/index/NB120-7838&prev_module=search#f populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression. Br J Cancer 62:430-5 (1990). Bouchard L et al. Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene. Cell 57:931-6 (1989).
Additional info: Specific against human c-erbB-2 oncoprotein. Labels epithelial cells in approximately 20% of cases of adenocarcinomas from various sites such as breast, ovary, and gastrointestinal tract. Species Crossreactivity: Crossreacts with Human.

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