c-erbB3, CT (HER 3, ErbB3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, MGC88033, p45 sErbB3, p85 sErbB3, p180 ErbB3)

Amplification of this gene and/or over expression of its protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. In breast cancer it has been shown to dimerize with ErbB2 to drive tumor cell proliferation.\n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:32,000\nWestern Blot: 0.1-0.3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C0026-08F

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in tris-saline, pH 7.3, 0.02% sodium azide, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Plowman, G. D. et al. (1990) Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc. Natl. Acad. Sci. USA 87: 4905-4909. 2. Holbro, T. et al. (2003) The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A. Jul 2003; 100: 8933.

Additional Info

Recognizes human ErbB3, CT. Species sequence homology: rat, mouse, dog.

Alternative Names

Receptor Tyrosine Protein Kinase erbB3, Tyrosine Kinase Type Cell Surface Receptor HER3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian)