Home  >  Products  >  c-erbB3, CT (HER 3, ErbB3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, MGC88033, p45 sErbB3, p85 sErbB3, p180 ErbB3)
c-erbB3, CT (HER 3, ErbB3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, MGC88033, p45 sErbB3, p85 sErbB3, p180 ErbB3)

c-erbB3, CT (HER 3, ErbB3, ErbB-3, erbB3-S, HER3, LCCS2, MDA-BF-1, MGC88033, p45 sErbB3, p85 sErbB3, p180 ErbB3)

Cat no: C0026-08F

Supplier: United States Biological
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Amplification of this gene and/or over expression of its protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. In breast cancer it has been shown to dimerize with ErbB2 to drive tumor cell proliferation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.1-0.3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C0026-08F
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in tris-saline, pH 7.3, 0.02% sodium azide, 0.5% BSA.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Receptor Tyrosine Protein Kinase erbB3, Tyrosine Kinase Type Cell Surface Receptor HER3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian)
References: 1. Plowman, G. D. et al. (1990) Molecular cloning and expression of an additional epidermal growth factor receptor-related gene. Proc. Natl. Acad. Sci. USA 87: 4905-4909. 2. Holbro, T. et al. (2003) The ErbB2/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation. Proc Natl Acad Sci U S A. Jul 2003; 100: 8933.
Additional info: Recognizes human ErbB3, CT. Species sequence homology: rat, mouse, dog.

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