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c-Fos (Fos)

c-Fos (Fos)

Cat no: C0030-01N

Supplier: United States Biological
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The Fos gene family consists of 4 members, Fos, FosB, FosL1 and FosL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP1. As such, the Fos proteins have been implicated as regulators of cell proliferation, differentation, and tranformation. In some cases, expression of the Fos gene has also been associated with apoptotic cell death. The human oncogene c-Fos is homologous to the Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus oncogene. Fos was the first transcription factor identified that has a criticial function in regulating the development of cells destined to form and maintain the skeleton. Fos protein is routinely used as a marker of neuronal activation. Applications: Suitable for use in Immunofluorescence and Western Blot. Not suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunofluorescence (IC): 2.5-5ug/ml Western Blot: 2.5-5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0030-01N
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunofluorescence, Western Blot
Size: 100ug
Form: Supplied as a liquid in 50mM sodium phosphate buffer, 0.2% gelatin; pH 7.5, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified
Alternative names: Cellular oncogene fos, FBJ murine osteosarcoma viral v fos oncogene homolog, FBJ Osteosarcoma Virus, FOS protein, G0 G1 switch regulatory protein 7, G0S7, Oncogene FOS, Proto oncogene protein c fos, v fos FBJ murine osteosarcoma viral oncogene homolog
References: 1. Jensen, D.E., et al. Defective induction of Jun and Fos-related proteins in phorbol ester-resistant EL4 mouse thymoma cells. Oncogene 6:1219-2125 (1991). 2. Reiss, M. et al. Constitutive expression of the c-fos protooncogene in murine keratinocytes: potentiation of the mitogenic response to insulin-like growth factor, Cancer Res 50: 6641-6448 (1990). 3. Rauscher, F.J. et al. Fos-associated protein p39 is the product of the jun proto-oncogene. Science 240: 1010-1016 (1988). 4. Sassone-Corsi P et al. fos-associated cellular p39 is related to nuclear transcription factor AP-1. Cell 54: 553-560 (1988).
Additional info: Recognizes the cellular and viral form of human c-Fos. Reacts with both the ~55kD and ~62kD c-Fos and v-Foc proteins but does not react with the ~39kD jun protein. Species Crossreactivity: mouse and rat.

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