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c-Jun

c-Jun

Cat no: C5815-01K

Supplier: United States Biological
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The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000 Optimal dilutions to be determined by the researcher. Recommended Secondary Antibodies: I1906 IgY, Chicken Pab Rb x Ch I1906-10 IgY, Chicken (HRP) Rb x Ch I1906-12 IgY, Chicken (FITC) Rb x Ch I1906-14 IgY, Chicken (AP) Rb x Ch Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5815-01K
Reactivities: Human, Mouse, Rat
Hosts: Chicken/Bird
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.2.
P type: Pab
Isotype: IgY
Purity: Purified by immunoaffinity chromatography.
Alternative names: AP1, Activator Protein 1, Enhancer Binding Protein AP1, JUN, JUN protein, JUNC, Jun Activation Domain Binding Protein, Jun oncogene, Proto oncogene cJun, Transcription Factor AP1, V jun avian sarcoma virus 17 oncogene homolog, p39, vJun Avian Sarcoma Virus 17 Oncogene Homolog
References: Eferl R et al. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 112:181-92 (2003).
Additional info: Recognizes human c-Jun at ~40kD. Species Crossreactivity: mouse, rat.

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