Home  >  Products  >  c-Jun, phosphorylated (Thr239) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)
c-Jun, phosphorylated (Thr239) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)

c-Jun, phosphorylated (Thr239) (Transcription Factor AP-1, Activator Protein 1, AP1, Proto-oncogene c-Jun, V-jun Avian Sarcoma Virus 17 Oncogene Homolog, p39, JUN)

Cat no: C5815-10S

Supplier: United States Biological
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The human protooncogene JUN is the putative transforming gene of avian sarcoma virus 17, and it encodes a protein which is highly homologous to the viral protein. cJun (previously known as the Fos binding protein p39) and c Fos form a complex in the nucleus. AP 1 (activating protein 1) is a collective term referring to these dimeric transcription factors composed of Jun, Fos or ATF subunits that bind to a common DNA site, the AP1 binding site. AP 1 proteins, mostly the Jun group, regulate the expression and function of cell cycle regulators such as Cyclin D1, p53, p21 (cip1/waf1), p19 (ARF) and p16. Fos and Jun proto oncogene expression is induced transiently by a variety of extracellular stimuli associated with mitogenesis, differentiation processes or depolarization of neurons. JUN has been mapped to 1p32 to p31, a chromosomal region involved in both translocations and deletions in human malignancies. Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1,000 Immunohistochemistry: 1:50-1:100 Immunofluorescence: 1:100-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C5815-10S
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human c-Jun when phosphorylated at threonine 239. Species Cross-Reactivity: mouse, rat.

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