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c-Kit, phosphorylated (Tyr721) (Mast/Stem Cell Growth Factor Receptor, SCFR, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, CD117, KIT)

c-Kit, phosphorylated (Tyr721) (Mast/Stem Cell Growth Factor Receptor, SCFR, Proto-oncogene c-Kit, Tyrosine-protein Kinase Kit, CD117, KIT)

Cat no: C2448-20B

Supplier: United States Biological
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c-Kit, a 145kD Type III transmembrane Tyrosine Kinase receptor, is a novel member of Ig superfamily. It consists of an extracellular domain with Ig-like repeats and a Tyrosine Kinase domain, a putative transmembrane region and a cytoplasmic domain. c-Kit functions as receptor for MGF/SCF resulting in maturation of hemopoietic and primordial germ cell precursors and melanocytes during embryonic development. The protein gets autophosphorylated and activates signaling pathways including PI3K/Akt, MAPK and JNK affecting multiple cellular functions including cell survival, proliferation, adhesion and differentiation. Mutations in c-Kit are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia and piebaldism. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Positive Control: 293T cells Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C2448-20B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Kitamura, YH. et.al. Cell. Mol. Life. Sci. 61:2924-2931 (2004).
Additional info: Recognizes human c-Kit, phosphorylated at Tyr721. Species Crossreactivity: mouse and rat.

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