Members of the Maf family of basic region/leucine zipper (bZIP) transcription factors affect transcription in either a positive or negative fashion, depending on their particular protein partner and the context of the target promoter. c-Maf (Maf-2) and the closely related family members Neural retina leucine zipper (Nrl), L-Maf, and Krml1/MafB (Maf-1) all bind to T-MARE sites and have been implicated in a wide variety of developmental and physiologic roles. The three small Maf family proteins (MafF, MafG, and MafK) are components of NF-E2 that function as heterodimers with the large tissuerestricted subunit of NF-E2 called p45, and they are implicated in the transcriptional regulation of many erythroid-specific genes.