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c-Myc (Myc Proto-oncogene Protein, Class E Basic Helix-loop-helix Protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription Factor p64, BHLHE39, MYC)

c-Myc (Myc Proto-oncogene Protein, Class E Basic Helix-loop-helix Protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription Factor p64, BHLHE39, MYC)

Cat no: C0035-09C

Supplier: United States Biological
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C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells,in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol (2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo. Applications: Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry, and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 4ug/ml Immunohistochemistry (paraffin): 8ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C0035-09C
Reactivities: Human, Mouse, Rat
Hosts: Mouse
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder from 1.2% sodium acetate, 2mg BSA, 0.01mg sodium azide. Reconstitute with 1.2% sodium acetate, PBS.
P type: Mab
Isotype: IgG2a
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human c-Myc. Species Crossreactivity: mouse, rat.

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