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c-Myc (Myc Proto-oncogene Protein, Class E Basic Helix-loop-helix Protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription Factor p64, BHLHE39, MYC)

c-Myc (Myc Proto-oncogene Protein, Class E Basic Helix-loop-helix Protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription Factor p64, BHLHE39, MYC)

Cat no: C0035-09M

Supplier: United States Biological
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The protooncogene Myc, homologous to the transforming gene v-myc of myelocytomatosis virus MC29 is basically a transcription regulator activating various genes like PAI-1, alpha-prothymosin etc. Myc contains a basic region, helix-loop-helix zipper (B-HLZ-LZ) DNA binding domain, a hallmark of transcription factor that dimerizes with its partner, Max, and regulates multiple cellular functions including cell cycle, cell growth, differentiation, apoptosis, metabolism, and angiogenesis via transcription of downstream target genes. The pathological role of the protein has been observed in hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma and B-cell chronic lymphocytic leukemia. Human Myc gene is mapped to chromosome 8q24.21. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochemistry (Formalin fixed paraffin embedded): 10ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0035-09M
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 40ug
Form: Supplied as a liquid in PBS without Mg2+, Ca2+, pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human Myc. Species sequence homology: Mouse, rat.

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