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C-Peptide (Hyperproinsulinemia, Insulin Precursor, IRDN, Proinsulin)

C-Peptide (Hyperproinsulinemia, Insulin Precursor, IRDN, Proinsulin)

Cat no: C7905-01R

Supplier: United States Biological
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C-peptide is a 31 amino acid peptide released when proinsulin is split into insulin and C-peptide. In rats, two isoforms of proinsulin exists, the difference is two amino acid residues in the C-peptide, termed C-peptide I and C-peptide II. Proinsulin is split when it is released from the pancreas into the blood in response to a rise in serum glucose levels. C-peptide function is not fully understood, it binds to cell membranes which leads to increased intracellular Ca2+ concentration and subsequent stimulation of N+, K+-ATPase and endothelial nitric oxide synthase activities. C-peptide also functions in repair of the muscular layer of arteries. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilutions: ELISA: Used in indirect ELISA or as a detection antibody in a sandwich ELISA with C7905-01Q as a capture antibody. The sandwich ELISA is only suitable for the detection of rat and not mouse C-peptide I or II. Optimal dilutions to be determined by the researcher. Hybridoma: Sp2/0 myeloma cells with spleen cells from Balb/c mice. Recommended Secondary Antibodies: I1904-23: IgG, X-Adsorbed (FITC) Pab Gt xMo I1904-65W: IgG, F(ab
Catalogue number: C7905-01R
Reactivities: Mouse, Rat
Hosts: Mouse
Applications: ELISA
Size: 200ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography.
Additional info: Recognizes an epitope in the N-terminal region of rat C-peptide I and II with almost equal affinity. Species Crossreactivity: mouse. Reacts very weakly with rat proinsulin.

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