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C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

Cat no: C7907-04D

Supplier: United States Biological
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Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to hosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. COFACTOR: Binds 2 calcium ions per subunit. Subunit: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Cellular Localization: Secreted protein. Alternative Products: 2 named isoforms produced by alternative splicing. Tissue Specificity: Found in plasma. The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL-1 and IL-6. This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium. Belongs to the pentaxin family. Contains 1 pentaxin domain. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C7907-04D
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ul
Form: Supplied as a lyophilized powder. Reconstitute in 100ul of sterile water. Centrifuge to remove any insoluble material.
P type: Pab
Purity: Serum
Alternative names: C reactive protein pentraxin related, CRP, MGC88244, PTX 1, PTX1
References: 1. Lei K.-J, et al. J. Biol. Chem. 260:13377-13383(1985). ; 2. Woo P, et al. J. Biol. Chem. 260:13384-13388(1985). ; 3. Gregory S.G, et al. Nature 441:315-321(2006). ; 4. Tucci A, et al. J. Immunol. 131:2416-2419(1983). ; 5. Whitehead A.S, et al. Science 221:69-71(1983). ; 6. Oliveira E.B, et al. J. Biol. Chem. 254:489-502(1979). ; 7. Osmand A.P, et al. Proc. Natl. Acad. Sci. U.S.A. 74:1214-1218(1977). ; 8. Kiernan U.A, et al. Clin. Proteomics 1:7-16(2004). ; 9. Srinivasan N, et al. Structure 2:1017-1027(1994). ; 10. Shrive A.K, et al. Nat. Struct. Biol. 3:346-353(1996).
Additional info: Specific for C-reactive protein by WB. Species Crossreactivity: Human

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