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C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

C-Reactive Protein (CRP, MGC88244, PTX 1, PTX1)

Cat no: C7907-23

Supplier: United States Biological
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C-reactive protein (CRP) is a calcium-binding acute phase reactant belonging to the pentraxin family which is secreted into the plasma by the liver, in response to cytokine stimulation. In addition to binding to phosphocholine residues, CRP can bind to other autologous and extrinsic ligands on targets, including damaged cell membranes, ribonucleoprotein particles, apoptotic cells and constituents of micro-organisms, and may activate the classical complement pathway through C1q recognition, making CRP a factor in a variety of host defense mechanisms. Levels of plasma CRP are significantly increased during the acute phase response, tissue injury and infection and can be used diagnostically as a marker of inflammation, disease progress and risk assessment of cardiovascular disease (CVD). Applications: Suitable for use in ELISA and Immunodiffusion. Other applications have not been tested. Recommended Dilution: ELISA : 1:1000 -1:15,000 Immunodiffusion: 1:30-1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C7907-23
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 1ml
Form: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by affinity chromatography.
Alternative names: CRP
References: 1. Pepys, M.B. and Hirschfield, G.M. (2003) C-reactive protein: a critical update. J. Clin. Invest. 111:1805-1812. 2. Clearfield, M.B. (2005) C-reactive protein: A new risk assessment tool for cardiovascular disease. JAOA. 105:409-416.
Additional info: Recognizes human C-reactive protein.

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