C-Reactive Protein, Recombinant, Human (CRP, MGC88244, PTX 1, PTX1)

CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.\n\nRecombinant Human C-Reactive Protein is a non-glycosylated polypeptide chain having a total molecular mass of 115kD that corresponds to the pentamer structure of 23kD monomer determined by amino acid sequence.\n\nStorage and Stability:\nAliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C7907-28

Size

500ug

Form

Supplied as a liquid in 20mM Tris, pH 7.5, 2mM calcium chloride, 0.14M sodium chloride, 0.05% sodium azide.

Purity

Purified by affinity chromatography. A band at ~23kD is detected by SDS-PAGE.

References

1. C-reactive protein: crystal ball or redundancy? Is this heart risk biomarker useful independently, or does it only confirm the results of other tests? Health News 10(12): 3 (2004, Dec). 2. Nissen, S.E., Tuzcu, E.M., Crowe, T., Magorien, R.D.: Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N. Engl. J. Med. 352(1): 29-38 (2005, Jan 6). 3. Ridker, P.M., Cannon, C.P., Rifai, N., Braunwald, E.: C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. 352(1): 20-8 (2005, Jan 6). 4. Hammett, C.J., Oxenham, H.C., Doughty, R.N., Stewart, R.A.: Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. J. Am. Coll. Cardiol. 44(12): 2411-3 (2004, Dec 21). 5. Niizuma, T., Terada, K., Daimon, Y., Tanaka, K.: Elevated serum C-reactive protein in mumps orchitis. Pediatr. Infect. Dis. J. 23(10): 971 (2004, Oct). 6. Casamassima, A., Picciariello, M., Berardino, R., Guida, M.: C-reactive protein: a biomarker of survival in patients with metastatic renal cell carcinoma treated with subcutaneous interleukin-2 based immunotherapy. J. Urol. 173(1): 52-5 (2005, Jan).