C-Reactive Protein, Recombinant, Human (CRP, MGC88244, PTX 1, PTX1)

CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically (up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels.\n\nRecombinant CRP is a pentamerized active molecule secreted into culture medium during E.coli fermentation with host cells having human CRP gene, allowing r-hCRP to be excreted without cell lysis. The patented technology specifies only active r-hCRP to be manufactured, which is equivalent to native one originated from human tissues. The recombinant CRP is affinity-purified by use of phosphorylcholine conjugated matrices. As a result, the final product presents the longest stability for 2 years as supplied refrigerated.\n\nApplications: Standard antigen for CRP determination, rhCRP has been evaluated as a secondary reference material to meet standardization of high sensitive CRP assay. High qualified antigen for antibody production.

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SPECIFICATIONS

Catalog Number

C7907-28B

Size

100ug

Form

Supplied as a liquid with buffer.

Purity

Purified by immunoaffinity chromatography. (same/more than) 96% by SDS-PAGE

References

1. C-reactive protein: crystal ball or redundancy? Is this heart risk biomarker useful independently, or does it only confirm the results of other tests? Health News 10(12): 3 (2004, Dec). 2. Nissen, S.E., Tuzcu, E.M., Crowe, T., Magorien, R.D.: Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N. Engl. J. Med. 352(1): 29-38 (2005, Jan 6). 3. Ridker, P.M., Cannon, C.P., Rifai, N., Braunwald, E.: C-reactive protein levels and outcomes after statin therapy. N. Engl. J. Med. 352(1): 20-8 (2005, Jan 6). 4. Hammett, C.J., Oxenham, H.C., Doughty, R.N., Stewart, R.A.: Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. J. Am. Coll. Cardiol. 44(12): 2411-3 (2004, Dec 21). 5. Niizuma, T., Terada, K., Daimon, Y., Tanaka, K.: Elevated serum C-reactive protein in mumps orchitis. Pediatr. Infect. Dis. J. 23(10): 971 (2004, Oct). 6. Casamassima, A., Picciariello, M., Berardino, R., Guida, M.: C-reactive protein: a biomarker of survival in patients with metastatic renal cell carcinoma treated with subcutaneous interleukin-2 based immunotherapy. J. Urol. 173(1): 52-5 (2005, Jan).