C1s (49) Antibody

Cat no: 250214

Supplier: ABBIOTEC

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Description
Additional Information

C1s proenzyme is a 79.8 kDa glycoprotein produced primarily by hepatocytes but also by other cells. The proenzyme is produced as a single-chain polypeptide of 688 aa. Upon activation the peptide is cleaved between R437 and I438 giving the activated enzyme consisting of two disulfide-linked chains, A chain (52.2 kDa) and B chain (27.7 kDa). The Ca-dependent catalytic subunit of the C1 comple, Xenopus/Amphibian, (C1q, C1r, C1s) comprises of two C1s and two C1r molecules and this serine protease tetramer is responsible for the initial steps in the classical complement pathway, cleavage of C4 and C2. This antibody is specific for C1s proenzyme and activated free C1s and C1s in comple, Xenopus/Amphibian, with C1 inhibitor.

Catalogue number:	250214
Reactivities:	Human
Size:	0.2 mg
Accession:	P09872
Antigen:	Human plasma C1s Proenzyme
Format:	Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG1/k
Clonality:	49
Additional info:	C1 Esterase