C3 Complement beta-chain variant (8G4) Antibody

Cat no: 250286

Supplier: ABBIOTEC

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Description
Additional Information

C3 is a key component of the complement system since classical and alternative activation pathways merge at the C3 activation step when C3 is split into C3a and C3b. The molecular mass of C3 is 185 kDa and it consists of alpha and beta chains (110 kDa and 75 kDa respectively) held together by disulfide bonds. This antibody is specific for an allotypic marker on human C3 (Leu instead of Pro in codon 314 of e, Xenopus/Amphibian,on 9), which occurs regularly in the beta-chain of C3F and occasionally in the beta-chain of C3S (F and S meaning fast and slow migration rate, respectively, on agarose gel electrophoresis). The antibody reacts with the 75-kDa beta-chain band of reduced C3 in immunoblotting , and reacts with the 20-kDa and 17-kDa beta-chain fragments produced by cyanogen bromide cleavage.

Catalogue number:	250286
Reactivities:	Human
Applications:	Western Blot
Size:	0.1 mg
Accession:	P01024
Antigen:	C3 isolated from human plasma
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography.
P type:	Mouse Monoclonal Antibody
Isotype:	Mouse IgG2a/k
Clonality:	8G4
Additional info:	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3; C3a anaphylato, Xenopus/Amphibian,in; Complement C3b alpha chain; Complement C3c alpha chain fragment 1; Complement C3dg fragment; C3d fragment; C3g fragment; C3f fragment; C3c alpha chain fragment 2