Home  >  Products  >  C646 ((E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid)

C646 ((E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid)

Cat no: 044620


Supplier: United States Biological
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Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C. Store solutions at -20 degrees C in the dark.
Catalogue number: 044620
Size: 1mg
Purity: >98% (NMR)
Alternative names: (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid
References: Product Reference: ?Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor: E.M. Bowers, et al.; Chem. Biol. 17, 471 (2010) ?HAT Trick: p300, Small Molecule, Inhibitor: M. Ott & E. Verdin; Chem. Biol. 17, 417 (2010) ?Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetics remodeling and the expression of pluripotency-associated genes: P. Mali, et al.; Stem Cells 28, 713 (2010) ?Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP: N.T. Crump, et al.; PNAS 108, 7814 (2011) ?Paradoxical Enhancement of Fear Extinction Memory and Synaptic Plasticity by Inhibition of the Histone Acetyltransferase p300: R. Marek, et al.; J. Neurosci. 31, 7486 (2011) ?Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines: F.R. Santer, et al.; Mol. Cancer Ther. (Epub ahead of print) (2011) ?

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